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“My female Doberman was having some vaginal discharge that looked suspicious.  I used a Tissue (Wipe & Know) and it changed the color that indicated she needed antibiotics!  I immediately called my Repro vet and took her in for an evaluation.  The vet agreed it was a bacterial infection, that it could be early Pyometra, my vet prescribed an antibiotic right away.  My dog did very well and fully recovered."